Hypervitaminosis A and Scurvy

Cxix. Hypervitaminosis and Vitamin

THE object of this paper is to record a continuation of experiments in which the existence is demonstrated of a "balance" between the vitamin B complex on the one hand and vitamins A and D of cod-liver oil on the other. Only two previous communications bearing directly on this subject have appeared in the literature, so far as we are aware. In the first place, Hopkins [1923] mentioned that he h...

Scurvy

HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS

In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...

Scurvy

Scurvy

People write to ask me if the dose is to be half a drachm or half an ounce, so it is as well to say half an ounce unmistakably, or the drug might fall into undeserved disrepute. I am asked if the patients whose swollen legs I describe may not have been suifering from Beri-beri. I believe not. The cases yielded readily to the usual antiscorbutic treatment, while Beri-beri requires turpentine.